ANTI-NUDT1 ANTIBODY PRODUCED IN RABBIT

Code: SAB5700089-100UL D2-231

General description

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogene...


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General description

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human NUDT1 (NP_945192.1).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
concentration1.91 mg/ml
formbuffered aqueous solution
Gene Informationhuman ... NUDT1(4521)
mol wt20, 22, 19, 17
Quality Level100
shipped inwet ice
species reactivityhuman
storage temp.−20°C
technique(s)immunohistochemistry: 1:50-1:200, immunoprecipitation (IP): 1:20-1:50, western blot: 1:500-1:2000
UniProt accession no.P36639
This product has met the following criteria to qualify for the following awards:



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